Healthy joints and bones

MAINTAINING HEALTHY JOINTS AND BONES

The effectiveness of collagen peptides in supporting joint health is supported by numerous scientific studies. As people lead active lifestyles and want to remain mobile for longer, they are becoming increasingly aware that joint and bone health should be taken care of from an early age. Concern for the health of the musculoskeletal system does not only apply to elderly adults. Even those who exercise occasionally (once or twice a week) can experience the strain on their joints.

Collagen is a key component of cartilage tissue and maintaining its integrity is essential for the preservation of healthy and flexible joints. Bones are a tissue that constantly undergoes a balanced process of breakdown-renewal to keep them healthy and avoid brittleness. As with joints, collagen is one of the key building blocks of bone - it accounts for 90% of organic bone mass. It provides an organic structure on which minerals are deposited and also contributes to maintaining flexibility and strength. The bone health can deteriorate with age or as a result of one' s lifestyle. Collagen peptides - which are a pure protein - can help maintain bones in a healthy condition.

SCIENTIFIC RESEARCH

Discover the scientific evidence proving the effectiveness of Peptan in supporting the maintenance of healthy joints and bones.

• Peptan IIm for healthy joints - Peptan IIm, derived from natural raw materials, is a unique hydrolysed cartilage matrix containing bioactive type II collagen peptides, as well as chondroitin sulphate and hyaluronic acid. These components provide effective protection for cartilage against degeneration, as confirmed by scientific studies [4].
• Peptan IIm - Scientific research - In an in vivo study [4], Peptan IIm was shown to effectively support joint health at low daily doses. It has been proven that in models of post-traumatic osteoarthritis in animals with both normal weight and those with obesity, Peptan IIm protects cartilage from degeneration and promotes lubrication as well as showing anti-inflammatory effects (using the knee joint as an example).

• 
  Peptan helps to maintain healthy joints - In a clinical trial [5] of 94 women aged 40-70 years reporting knee joint problems, 8 g of Peptan or placebo was used daily for 6 months. In the Peptan treatment group, there was a 22% reduction in the WOMAC score, combined with a reduction in joint pain (by 32%) and an improvement in firmness (44%).
• 
  Peptan supports healthy bones - A 2010 study [6] demonstrated that Peptan stimulates the activity of bone-forming cells while inhibiting the function of bone resorbing cells. This result is confirmed by further studies from 2012 and 2014 [7, 8].

Bibliography:

1. Slowing down the clock with collagen peptides. White paper PEPTIDES. 2021; (January): 24–26.
2. Asserin J., Lati E., Shioya T., et al. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015; 14(4): 291–301. doi: 10.1111/jocd.12174. PMID: 26362110.
3. Clifford T., Ventress M., Allerton D. M., et al. The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial. Amino Acids. 2019; 51(4): 691–704. doi: 10.1007/s00726-019-02706-5. PMID: 30783776.
4. Soniwala S., Scinto K. I., Schott E. M., et al. Oral hydrolyzed type 2 collagen protects against the OA of obesity and mitigates obese gut microbiome dysbiosis. Osteoarthritis and Cartilage. 2018; 26: S173–S174. doi: 10.1016/j.joca.2018.02.377.
5. Jiang J. X., Yu S., Huang Q. R., et al. Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study. Agro Food Industry Hi Tech. 2014; 25(2): 19–23.
6. Guillerminet F., Beaupied H., Fabien-Soulé V., et al. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone. 2010; 46(3): 827–834. doi: 10.1016/j.bone.2009.10.035. PMID: 19895915.
7. Guillerminet F., Fabien-Soulé V., Even P. C., et al. Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporos Int. 2012; 23(7): 1909–1919. doi: 10.1007/s00198-011-1788-6. PMID: 21927918.
8. Daneault A. Hydrolyzed collagen contributes to osteoblast differentiation in vitro and subsequent bone health in vivo. Osteoarthritis Cartilage. 2014; 22: S131. doi: 10.1016/j.joca.2014.02.240.
9. Hays N. P., Kim H., Wells A. M., et al. Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older women. J Am Diet Assoc. 2009; 109(6): 1082–1087. doi: 10.1016/j.jada.2009.03.003. PMID: 19465192.